Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward

Reward-seeking behavior is frequently associated with risk of punishment.There are two types of punishment: positive punishment, which is defined as addition of an aversive stimulus, and negative punishment, involves the omission of a rewarding outcome.Although the medial prefrontal cortex (mPFC) is important in avoiding punishment, whether it is i

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